3R Resources & Links

3 Minute 3Rs

The 3R podcast by NC3Rs and Lab Animals provides you with the latest 3R News in just 3 minutes.

Websites with 3R resources


The Biomedical Research for the 21st Century (BioMed21) Collaboration

This collaboration brings together scientists and institutions from across Europe, Asia and the Americas who share a vision of a new, human-focused paradigm in health research.



Culture of Care Network

The term Culture of Care is used in the laboratory animal community to indicate a commitment to improving animal welfare, scientific quality, care of the staff and transparency for the stakeholders. The networks provides resources on Culture of Care.



DC 3Rs - Inventory of 3Rs Knowledge Sources

A study carried out by the European Commission’s Joint Research Centre compiled knowledge sources (websites, publications, databases, organisations, events, expert groups, etc.) relevant to the 3Rs. This study, is now available.

To make the most of this knowledge base, DC has developed an online application to allow sharing. Theapp allows the user to consult 3Rs knowledge sources listed in the JRC study.



EURL ECVAM Search Guide

The EURL ECVAM Search Guide provides search principles and procedures, suggested search terms and user guidance together with an inventory of relevant information resources to support untrained database users in finding high quality information on relevant alternative strategies and methods. 

It can be downloaded (pdf) or requested in paper copy (for free) from the EU Bookshop.


MERIDIAN network

Menagerie of Reporting Guidelines Involving Animals

MERIDIAN collects all reporting guidelines for research involving animals, including biomedical, preclinical, livestock, and veterinary research that involves biomedical, companion, and food product animals.


NCR3s Resource Hub






Refinement Wiki





Replacement Resources


Database for alternative methods to animal experiments.




Resources for Alternatives to the Use of Live Vertebrates in Biomedical Research and Testing


EURL ECVAM DataBase on ALternative Methods (DB-ALM)

Collection of data-sets providing factual information (not only bibliographic references) presented as evaluated (and therefore ready-to-use) data sheets.


The FCS-free Database

Fetal Calf Serum (FCS, also known as Fetal Bovine Serum, or FBS) is a common supplement of animal cell culture media. However, moral and scientific concerns demonstrate the urgency to switch to an FCS-free medium. The FCS-free Database, part of the 3Rs Database Programme, provides an overview of FCS-free media for cell-culture. A forum function for each record allows researchers to discuss the applicability of each product. The database is offered by the 3Rs-Centre ULS in collaboration with Animal Free Research UK.

see also SEFREC (Serum free cell lines)


The ISSG search filter

This Search Filter Resource is a collaborative venture to identify, assess and test search filters designed to retrieve research by study design or focus. The Search Filters Resource aims to provide easy access to published and unpublished search filters. It also provides information and guidance on how to critically appraise search filters, study design filters in progress and information on the development and use of search filters. Inclusion of a search filter is not an endorsement of its validity or a recommendation.
ISSG filters


Swiss biobanking platform

SBP is the national coordination platform for human and non-human biobanks. It aims to respond to the increasing requests from biomedical researchers regarding quality and the interconnectedness of biobanks for research purposes.



VirtualToxLab - Biograf 3R

The VirtualToxLab is an in silico tool for predicting the toxic potential (endocrine and metabolic disruption, some aspects of carcinogenicity and cardiotoxicity) of drugs, chemicals and natural products.


The European Organ-on-Chip Society (EUROoCS)

is an independent, not-for-profit organization established to encourage and develop Organ-on-Chip research, and to provide opportunities to share and advance knowledge and expertise in the field towards better health for all.


International and national 3Rs Centers



 Map of all European 3R Centers


The European Consensus-Platform for Alternatives


The Swiss 3Rs Competence Center


Swiss 3RCC