Publications Paulin Jirkof
Original Research Articles
- Thallmair M, Jirkof P. A scoping review on reporting of methods in DSS colitis mouse models. Laboratory Animals. 2025;0(0). doi:10.1177/00236772251331677
- Steiner S, Krzyzaniak O, Nilsson FAM, et al. Sex and strain differences in the micropipette-guided drug administration (MDA) method in mice. Laboratory Animals. 2025;0(0). doi:10.1177/00236772251320843
- Krzyzaniak, O., Steiner, S., Nilsson, F. A., Dietrich, M., Kämpfen, L., Johansen, P., ... & Meyer, U. (2025). Applicability of the micropipette-guided drug administration (MDA) method for assessing reward-related behaviors in mice. Physiology & Behavior, 114967.
Munk, A., Philippi, V., Buchecker, V., Bankstahl, M., Glasenapp, A., Blutke, A., Jirkof, P. ... & Potschka, H. (2024). Refining pain management in mice by comparing multimodal analgesia and NSAID monotherapy for neurosurgical procedures. Scientific Reports, 14(1), 18691.
- Wolter, A., Jirkof, P., Thöne-Reineke, C., Rapp, A. E., & Lang, A. (2024). Evaluating rearing behaviour as a model-specific pain indicator in mouse osteotomy models. Laboratory Animals, 58(1), 9-21.
- King, H., Reiber, M., Philippi, V., Stirling, H., Aulehner, K., Bankstahl, M., ..Jirkof, P.. & Potschka, H. Anesthesia and analgesia for experimental craniotomy in mice and rats: A systematic scoping review comparing the years 2009 and 2019. Frontiers in Neuroscience, 17, 595.10.3389/fnins.2023.1143109
- Spalinger M., Schwarzfischer M., Niechcial A., Atrott K., Laimbacher A., Jirkof P., & Scharl M. (2023). Evaluation of the effect of tramadol, paracetamol and metamizole on the severity of experimental colitis. Laboratory Animals, 00236772231163957.
- Wolter A., Bucher C. H., Kurmies S., Schreiner V., Konietschke F., Hohlbaum K.,... Jirkof P & Lang, A. (2023). A buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72 h in mouse femoral fracture models. Scientific Reports, 13(1), 3824.
- Talbot SR, Struve B, Wassermann L, Heider M, Weegh N, Knape T, Hofmann MCJ, von Knethe A, Jirkof P, Häger C, Bleich A (2022). RELSA—A multidimensional procedure for the comparative assessment of well-being and the quantitative determination of severity in experimental procedures. Frontiers in Veterinary Science, 9.
- Aulehner K, Leenaars C, Buchecker V, Stirling H, Schönhoff K, King H, Häger C, Koska I, Jirkof P, Bleich A, Bankstahl M, Potschka H (2022) Grimace scale, burrowing and nest building for the assessment of postsurgical pain in mice and rats - a systematic review. Frontiers in Veterinary Science, 9.
- Gkrouzoudi, A., Tsingotjidou, A., & Jirkof, P. (2022). A Systematic Review on Reporting of Refinements Measures in Mouse ECG Telemetry Implantation Surgery. Laboratory Animals, 00236772221115492.
- Tappe-Theodor A, Pitzer C, Lewejohann L, Jirkof P, Siegeler K, Segelcke A, Drude N, Pradier B, Pogatzki-Zahn EM, Hollinderbäumer B, Segelcke D (2022) The "WWHow" concept for prospective categorization of post-operative severity assessment in Rodents. Frontiers in Veterinary Science, 9.
- Gkrouzoudi A., Tsingotjidou A., & Jirkof P (2021). A Systematic Review on the Reporting Quality in Mouse Telemetry Implantation Surgery Using Electrocardiogram Recording Devices. Physiology & Behavior, 113645.
- Durst M, Reding Graf T, Graf R, Kron M, Arras M, Zechner D, Palme R, Talbot S, Jirkof P (2021) Analysis of pain and analgesia protocols in acute Cerulein-induced pancreatitis in male C57BL/6 mice. Frontiers in Physiology. https://doi.org/10.3389/fphys.2021.744638
- Wolter A, Rapp AE, Durst M, Hildebrand L, Löhning M, Buttgereit F, Schmidt-Bleek K, Jirkof P, Lang A (2021) Systematic review on the reporting accuracy of experimental details in publications using mouse femoral fracture models. Bone, 116088.
- Schreiner V, Detampel P, Jirkof P, Puchkov M, Huwyler J (2021) Buprenorphine Loaded PLGA Microparticles: Characterization of a Sustained-Release Formulation. Journal of Drug Delivery Science and Technology. 63. https://doi.org/10.1016/j.jddst.2021.102558
- Durst M, Arras M, Palme R, Talbot S, Jirkof P (2021) Lidocaine and Bupivacaine as part of multimodal pain management in a C57BL/6J laparotomy mouse model. Scientific Reports. 11.1 (2021): 1-17.
- van der Mierden S, Leenaars CHC, Boyle EC, Ripoli FL, Gass P, Durst M, Goerlich-Jansson VC, Jirkof P, Keubler LM, Talbot SR, Habedank A, Lewejohann L, Tolba RH, Bleich A (2020) Measuring endogenous corticosterone in laboratory mice-a mapping review, meta-analysis, and open source database. ALTEX-Alternatives to animal experimentation.
- Schreiner V, Durst M, Arras M, Detampel P, Jirkof P, Huwyler J (2020) Design and In Vivo Evaluation of a Microparticulate Depot Formulation of Buprenorphine for Veterinary Use. Scientific Reports.
- Jirkof P, Bratcher, N., Medina, L. et al. (2020) The effect of group size, age and handling frequency on inter-male aggression in CD 1 mice. Scientific Reports. 10, 2253. https://doi.org/10.1038/s41598-020-59012-4
- Jirkof P, Rudeck J, Lewejohann L (2019) Assessing Affective State in Laboratory Rodents to Promote Animal Welfare—What Is the Progress in Applied Refinement Research? Animals, 9(12), 1026; https://doi.org/10.3390/ani9121026
- Jirkof P, Durst M, Thöne-Reinecke C, Palme R, Lang A (2019) Administration of Tramadol or Buprenorphine via the drinking water for post-operative analgesia in a mouse-osteotomy model. Scientific Reports 9, 10749 doi:10.1038/s41598-019-47186-5
- Jirkof P., Abdelrahman A, Bleich A, Durst M, Keubler L, Potschka H, Struve B, Talbot S, Vollmar B, Zechner D, Häger C (2019) A safe bet? Inter-laboratory variability in behavior-based severity assessment. Laboratory Animals. https://doi.org/10.1177/0023677219881481
- Ernst L, Kopaczka M, Schulz M, Talbot S, Struve B, Häger C, Bleich A, Durst M, Jirkof P, Arras M, v. Dijk R, Miljanovic N, Potschka H, Merhof D, Tolba R (2019) Semi-automated generation of pictures for the Mouse Grimace Scale: a multilab analysis (Part II). Laboratory Animals. https://doi.org/10.1177/0023677219881664
- Leenaars CHC, van der Mierden S, Durst M, Goerlich-Jansson VC, Lüder Ripoli F, Keubler LM, Talbot SR, Boyle E, Habedank A, Jirkof P, Lewejohann L, Gass P, Tolba R, Bleich A (2019). Measurement of corticosterone in mice: a protocol for a mapping review. Laboratory Animals. https://doi.org/10.1177/0023677219868499
- Jirkof P, Schmutz J (2019) Social and organizational factors affecting biosafety compliance in animal facilities: An integrative analysis of safety rules within the system. Safety Science. 18:538-550. doi.org/10.1016/j.ssci.2019.05.053
- Evangelista-Vaz E, Bergadano A, Arras M, Jirkof P (2018) Evaluation of the analgesic efficacy of a 25 mg/kg Tramadol s.c. injection-oral combination in a surgical model in C57BL/6J mice. Journal of the American Association for Laboratory Animal Science. 57:4. DOI: 10.30802/AALAS-JAALAS-17-000118
- Jirkof P, Arras M, Cesarovic, N (2018) A Tramadol:Paracetamol combination for post-surgical pain treatment of mice via the drinking water. Applied Animal Behaviour Science. 189: 95-100. doi.org/10.1016/j.applanim.2017.09.021
- Lipiski M, Arras M, Jirkof P, Cesorovic N (2017) Premedication with Fentanyl-Midazolam improves Sevoflurane Anesthesia for Surgical Intervention in Laboratory Mice. Experimental Biology and Medicine. 242: 12, 1287-1298, doi. 10.1177/1535370217707730
- Jeger V, Arrigo M, Hildenbrand F, Müller D, Jirkof P, Hauffe T, Seifert B, Arras M, Spahn DR, Bettex D, Rudiger A (2017) Improving animal welfare using continuous nalbuphine infusion in a long-term rat model of sepsis. Intensive Care Medicine Experimental. 5: 23, doi.org/10.1186/s40635-017-0137-2
- Fleischmann T, Sauer M, Rülicke T, Arras M, Jirkof P (2016) Voluntary intake of paracetamol-enriched drinking water and its influence on the success of embryo transfer in mice. Research in Veterinary Science. 111: 85–92, doi.org/10.1016/j.rvsc.2016.12.005
- Sauer M, Fleischmann T, Lipiski M, Arras M, Jirkof P (2016) Buprenorphine for pain relief in mice: administration via the drinking water. Applied Animal Behaviour Science. 185: 103–112, doi.org/10.1016/j.applanim.2016.09.009
- Fleischmann T, Henke J, Jirkof P, Arras M, Cesarovic N (2016) Injection anaesthesia with fentanyl-midazolam-medetomidine in adult female mice: importance of antagonisation and peri-operative care. Laboratory Animals. 50 (4): 264-274, doi.org/10.1016/j.applanim.2016.09.009
- Husmann K, Arlt M, Jirkof P, Arras M, Born W, Fuchs B (2015) Primary tumour growth in an orthotopic osteosarcoma mouse model is not influenced by analgesic treatment with buprenorphine and meloxicam. Laboratory Animals. 49(4):284-93, doi: 10.1177/0023677215570989
- Jirkof P, Tourvielle A, Cinelli P, Arras M (2014) Buprenorphine for pain relief in mice: repeated injections vs sustained release depot formulation. Laboratory Animals. 49(3):177-87, doi: 10.1177/0023677214562849
- Schuler B, Arras M, Gianella M, Vogel O, Jirkof P, Cesarovic N, Klohs J, Jakob P, Baum O, Rieger G, Gubser M, Hoppeler H, Samillan-Soto V, Gassmann M, Fischer J, Born W, Vogel J (2014) Endogenous alpha calcitonin gene-related peptide (αCGRP) promotes physiological, exercise-induced cardiac hypertrophy. Acta Physiologica. 211(1):107-21, doi: 10.1111/apha.12244
- Wueest S, Item F, Boyle C, Jirkof P, Cesarovic N, Ellingsgaard H, Arras M, Donath M, Lutz T, Schoenle E, Konrad D (2014) Interleukin-6 as a mediator of early metabolic adaptation to fasting. American Journal of Physiology. 306(11): R861-7, doi: 10.1152/ajpregu.00533.2013
- Cesarovic N, Arras M, Jirkof P (2014) Impact of inhalation anaesthesia, surgery and analgesic treatment on home cage behaviour in laboratory mice. Applied Animal Behaviour Science. 157: 137–145, doi: 10.1016/j.applanim.2014.04.010
- Jirkof P, Fleischmann T, Cesarovic N, Rettich A, Vogel J, Arras M (2013) Assessment of post-surgical distress and pain in laboratory mice by nest complexity scoring. Laboratory Animals. 47:153-61, doi:10.1177/0023677213475603
- Jirkof P, Leucht K, Cesarovic N, Krebs M, Nicholls F, Rogler G, Hausmann M, Arras M (2013) Burrowing is a sensitive behavioral assay for monitoring general wellbeing during dextran sulfate sodium colitis in laboratory mice. Laboratory Animals. 47(4):274-83, doi:10.1177/0023677213493409
- Jirkof P, Cesarovic N, Rettich A, Arras M (2013) Housing of female mice in a new environment and its influence on post-surgical behaviour and recovery. Applied Animal Behaviour Science. 148, 209–217, doi: 10.1016/j.applanim.2013.08.006
- Cesarovic N, Jirkof P, Rettich A, Nicholls F, Arras M (2012) Combining sevoflurane anesthesia with injection of fentanyl-midazolam or S-ketamine in laboratory mice. Journal of the American Association for Laboratory Animal Science. 51(2):209–18
- Arras M, Glauser D, Jirkof P, Rettich A, Schade B, Cinelli P, Pinschewer D, Ackermann M (2012) Multiparameter telemetry as a sensitive screening method to detect vaccine reactogenicity in mice. PLoS ONE. 7(1): e29726, doi: 10.1371/journal.pone.0029726
- Jirkof P, Cesarovic N, Fleischmann T, Rettich A, Arras M (2012) Individual housing of female mice: influence on postsurgical behaviour and recovery. Laboratory Animals. 46(4):325-34, doi: 10.1258/la.2012.012027
- Cesarovic N, Jirkof P, Rettich A, Arras M (2011) Implantation of radiotelemetry transmitters yielding data on ECG, heart rate, core body temperature and activity in free-moving laboratory mice. Journal of Visualized Experiments. 57: e3260, doi: 10.3791/3260
- Cesarovic N, Nicholls F, Rettich A, Kronen P, Hässig M, Jirkof P, Arras M (2010) Isoflurane and sevoflurane provide equally effective anaesthesia in laboratory mice. Laboratory Animals. 44 (4):329-36
- Jirkof P, Cesarovic N, Rettich A, Nicholls F, Seifert B, Arras M (2010) Burrowing behavior as an indicator of post-laparotomy pain in mice. Frontiers in Behavioral Neuroscience. 4:165, doi:10.3389/fnbeh.2010.00165
Invited Review Articles
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Jirkof P (2017) Side effects of pain and analgesia in animal experimentation. Lab Anim (NY). 46(4):123-128, doi: 10.1038/laban.1216
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Jirkof P (2015) Effects of experimental housing conditions on recovery of laboratory mice. Lab Animal (NY). 44, 65 – 70, doi:10.1038/laban.662
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Jirkof P (2014) Monitoring Burrowing and Nest Building Behavior as Species-Typical Indicators of Animal Well-being in Mice. Journal of Neuroscience Methods. 234:139-46, doi: 10.1016/j.jneumeth.2014.02.001
Other Articles
- Tremoleda JL, Cederroth C, Jirkof P. Engaging on discussions about the use and the replacement of animals in research with young minds. Laboratory Animals. 2023;0(0). doi:10.1177/00236772221147134Jirkof P (2022) Refining Research to Improve the Lives of Laboratory Mice. Front. Young Minds. 10:954413. doi: 10.3389/frym.2022.954413
- Fachinformation: Tiergerechte Haltung von Wüstenrennmäusen im tierexperimentellen Bereich, Ausschuss Tiergerechte Haltung, GV SOLAS, 2021
- Fachinformation: Empfehlung zur Schmerztherapie bei Versuchstieren. Ausschuss Anesthesie und Analgesie, GV SOLAS , 2020
- Fachinformation: Tiergerechte Haltung von Laborkaninchen, Ausschuss Tiergerechte Haltung, GV SOLAS, 2020
- Lewejohann, L., Schwabe, K., Häger, C., & Jirkof, P. (2020). Impulse for animal welfare outside the experiment. Laboratory Animals.
- Jirkof P, Seebeck P (2019) Vital signs without handling or animal prep. Lab Anim. DOI: 10.1038/s41684-019-0290-1
- Riederer B, Bomzon A, Jirkof P (2017) Scientific Writing in the Laboratory Animal Sciences. Letter from the editors. Laboratory Animals. 51(3), 315-320
- Golledge H, Jirkof P (2016) Editorial: Score sheets and analgesia. Laboratory Animals. 50(6):411-413
- Fachinformation: Tiergerechte Haltung von Labormäusen, Ausschuss Tiergerechte Haltung, GV SOLAS, 2014
- Stellungnahme: Einzelhaltung von Mäusen zu Versuchszwecken, Ausschuss Tiergerechte Haltung, GV SOLAS, 2013
Book chapter
- Jirkof P, Potschka H, Taylor D (2023) Optimizing anesthesia and analgesia for specific research projects. In: Anesthesia and Analgesia in Laboratory Animals, 3rd Edition.
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Jirkof P, Lofgren J (2023) Anesthesia and analgesia in laboratory rodents. In: Anesthesia and Analgesia in Laboratory Animals, 3rd Edition.
- Jirkof P, Potschka H. Effects of untreated pain, anesthesia and analgesia in animal experimentation. In: Experimental Design and Reproducibility in Preclinical Animal Studies. ESLAV, 2021
- Baumans V, Brain P, Jirkof P, Hendriksen C. Chapter 14 Recognition of pain and distress. In Handbook on Laboratory Animal Science edited by van Zutphen, Baumans and Beynen. 2021